Sperm: Down for the Count

نویسندگان

  • A. Gabizon
  • R. Chisin
  • S. Amselem
  • S. Druckmann
  • R. Cohen
  • D. Goren
  • Y. Barenholz
چکیده

Pharmacokinetic and imaging studies in 19 patients receiving liposome-entrapped adriamycin (L-ADM) were carried out within the framework of a Phase I clinical trial (Gabizon et al., 1989a). The formulation of L-ADM tested consisted of 0.2 gM-extruded multilamellar vesicles composed of egg phosphatidylcholine, egg-derived phosphatidyl-glycerol (PG), cholesterol, and ADM intercalated in the fluid lipid bilayer. Plasma clearance of total drug extracted from the plasma after L-ADM infusion followed a biexponential curve with a pattern similar to that reported for free ADM. The plasma concentration of drug circulating in liposome-associated form was also measured in a subgroup of seven patients. Liposomeassociated drug was found to be rapidly cleared from plasma. Its ratio to nonliposome-associated drug appeared to correlate with liver reserve, with highest ratios in patients with normal liver function. Liposome clearance, as measured by the plasma concentration of PG in three patients was slower than the clearance of liposome-associated ADM, suggesting that liposomes lose part of their drug payload during circulation. To learn about the liposome organ distribution, imaging studies were carried out with "'Indium-deferoxamine labelled liposomes of the same composition. Liposomes were cleared predominantly by liver and spleen and to a lesser extent by bone marrow in seven out of nine patients. In two patients with active hepatitis and severe liver dysfunction, there was minimal liver uptake and increased spleen and bone marrow uptake. Except for

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Adverse effects of long-time exposure to formaldehyde vapour on testicular tissue and sperm parameters in rats

Formalin is widely used in industry and in medicine (as tissue fixative and disinfectant).It contains reactive molecules which have been known for its cytotoxic effects. To evaluate the effect of formalin exposure on the testicular tissue and sperm parameter from neonatal period through physical and sexual maturity, 28 male Wister rats were assigned into two equal test and control groups. The t...

متن کامل

Use of Follicular Output Rate to Predict Intracytoplasmic Sperm Injection Outcome

Objective The measurement of follicular output rate (FORT) has been proposed as a good indicator for evaluating follicular response to the exogenous recombinant folliclestimulating hormone (rFSH). This places FORT as a promising qualitative marker for ovarian function. The objective of the study was to determine FORT as a predictor of oocyte competence, embryo quality and clinical pregnancy aft...

متن کامل

Effect of tamoxifen on testosterone concentration and sperm count in adult male rats

Introduction: Tamoxifen is a nonstroidal antiestrogen prescribed for treatment of breast cancer. The aim of this study was to investigate the effect of tamoxifen on testosterone level in the serum and sperm count in the epididymis of adult male Wistar rats. Methods: Three groups of rats received 200, 400 and 600 µg/kg body weight tamoxifen dissolved in solvent (60% ethanol in physiological ...

متن کامل

The effect of Aluminium chloride injection in arcuate nucleus on sperm count and the weight of vas deferens and epididymis in rat

Aluminium is a blocker of voltage sensitive cakcium channels which intere the body from different soueces.this ion interferes with biological function of Ca++ion.because GnRH synthesis,secretion and spermatogenesis on vas deferens and epididymis sperm count and weight of these organs in male rats.the study was performed on four group of rats(n=49),in whom the arcuate nuleus was bilateraly cannu...

متن کامل

P-15: Study Of the Effect of Nicotine - Melatoninon Sperm Parameters in Adult Mouse

Background: Cigarette smoking is associated with impairment of testicular function. Nicotine is a major component of cigarette smoke.In the present study we aimed to study the effect of administration of nicotine-melatonin on sperm parameters in adult mouse. Materials and Methods: Male NMRI mice were divided into 4 groups: 1) control(normal saline) group 2) nicotine treated group 3) melatonin t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Environmental Health Perspectives

دوره 101  شماره 

صفحات  -

تاریخ انتشار 1993